The topic of science and research is of great importance for the competitiveness of regions, including the Metropole Ruhr. Competition for the brightest minds has long since begun and is increasingly influencing many companies’ choice of location. Like many other regions in Europe, the Ruhr metropolitan region is undergoing a transformation process from an industrial to an urban knowledge society. In the form of an interdisciplinary World Café on February 23, 2015, the participants collected ideas and visions for the WissensMetropole Ruhr. In moderated Expert Round II on April 24, 2015, the focus was on the development of initial pilot projects on five predefined topics.